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This protein, known as ChREBP, was soon recognized as the long-desired glucose-responsive transcription factor ( 2.4 Retinoid X receptor (RXR) and retinoic acid re94 ceptor (RAR) Retinoid X receptors (RXRs) and retinoic acid receptors (RARs) are members of the nuclear receptor superfamily, which are critical for mediating the effects of retinoids, metabolites of vitamin A, in various physiological processes, including lipid metabolism

Whether LCACs alter these cardiac ECC mechanisms via direct protein interactions, indirect local lipid domain alteration, or through non-specific membrane perturbations remains unclear and requires further investigation