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A clinical trial involving 42 PD patients (2:1 randomized to NAC or control) demonstrated that a 3-month NAC regimen (50 mg/kg intravenous weekly plus 600 mg oral twice daily, skipping oral doses on infusion days) significantly increased dopamine transporter binding compared with the control group

GSH is a major cofactor for GPX4, a selenium-dependent enzyme that reduces lipid hydroperoxides (PUFA-PL-OOH) to their corresponding non-toxic lipid alcohols (PUFA-PL-OH), thereby preventing membrane destabilization [20]

5 weeks: 35 daily doses

PATHOPHYSIOLOGY OF OBESITY The etiology of obesity is complex

Nov-Dec 2002;22(6c):4179-4181