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Besides upregulating the expression of flagellar components, LCA itself is highly hydrophobic and therefore might also physically interact with flagella, potentially changing how the flagella interact with each other, with other bacterial cell surface components, and/or with the host mucosa
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Only Elamipretide and Bremelanotide are FDA approved with full safety data
These outcomes were significantly attenuated by the Nrf2 inhibitor ML385
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