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In hMDMs, specifically blocking DAT activity enhanced LPS-mediated production of IL-6, TNF- , and mitochondrial superoxide levels, showing that the regulation of dopamine uptake and release, as well as dopamine receptor activity, plays a role in dopaminergic immunomodulation in macrophages (Mackie et al., 2022)

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3 NO is produced via the action of an enzyme made by endothelial cells, called endothelial nitric oxide synthase (eNOS), on the amino acid L-arginine