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Hypoxia at the site of inflammation stimulates FLS to produce messenger RNAs such as CXCL12 and VEGF, resulting in a 50% and 132% increase in the protein levels of VEGF and CXCL12, respectively, after 24 hours of hypoxia (135)

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De plus, la production de glutathion peut tre altre par

Cellular ROS levels are determined by the balance between generation and elimination, a process regulated by antioxidant defense mechanisms 11

doi: 10.1186/s12943-024-02064-1 59 WangXFuS-QYuanXYuFJiQTangH-Wet al

Glutathione does not appear out of nowhere
