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Between 2 and 12% of patients receiving high-dose MTX therapy may get acute kidney injury, mostly as a result of crystal nephropathy caused by MTX and its metabolite, 7-OH-MTX

In healthy resting cells, this ratio exceeds 100, but it decreases to a range of 1 to 10 when cells are subjected to oxidative stress [29,83,98]

in 2021 employed a conplastic mouse model to assess the impact of mtDNA variations on joint aging (Scotece et al., 2021)

In both KEAP1 -mutant tumours and in some metastatic melanomas, loss of G6PD led to depletion of TCA cycle intermediates

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