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Thyrotoxicosis induced by administration of LT4 to healthy volunteers and those with thyroid nodules also induces a procoagulant state, associated with increased levels of FVIII, FIX, FX, VWF, fibrinogen D-dimer, and PAI-1 with delayed fibrin clot lysis and a shortening of the APTT, but with an inconsistent impact on clot structure parameters potentially based on subtle mechanistic differences between endogenous and iatrogenic hyperthyroidism [118,119,120,121]

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136 Another systematic review that included studies in elderly subjects also found heel ultrasound to be a reliable measure of BMD and fracture risk