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[210] have described an alternative calpain-dependent pathway of necroptosis induced by valproic acid (VPA) in the neuronal cell culture

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Indeed, optogenetic activation of vlPOA VGAT neurons potently induced hypothermia in Vgat-cre mice, as did chemogenetic silencing of DMH VGAT neurons, both of which induced neuroprotection by inhibiting cerebral reperfusion injury

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