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Gemcitabine Plus Ascorbate for Sarcoma in Adults (Pilot)

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Chronic hypoxiainduced hypogonadism likely contributes to loss of libido and general fatigability, which in turn reduce sexual activity

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Murphy et al, 2011

Cystine deficiency disrupts GSH synthesis while interfering with cystine/glutamate exchange, leading to intracellular glutamate accumulation that upregulates scavenger receptor CD36, promoting excessive oxidized lipid uptake and lipid peroxidation