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BAY 87-2243, a known inhibitor of IBa, upregulates Hmox1 in a nuclear factor manner independent of kb, thus promoting iron accumulation and inducing ferroptosis in tumor cells [129]

Investigations have highlighted many roles in which it is used including antioxidant defense, detoxification of electrophilic xenobiotics, modulation of redox regulated signal transduction, storage and transport of cysteine, regulation of cell proliferation, synthesis of deoxyribonucleotide synthesis, regulation of immune responses, and regulation of leukotriene and prostaglandin metabolism[13]

High-throughput deep mutational scanning, informed by AlphaFold, further pinpointed residues in CaErg11 that alter azole binding and resistance (Desprs et al., 2022)

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doi:10.1021/jp984796o