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Key Takeaways Gallbladder complications, such as gallstones, cholecystitis, and biliary dyskinesia, can affect certain patients taking retatrutide as a result of shifts in metabolism and bile flow

Challenges and future directions Currently, GLP-1RAs have shown potential for mitigating neurodegeneration

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They are indicated in combination with a reduced caloric diet and increased physical activity

these are usually taken with food, often once daily with the evening meal, but dosing should follow the specific product's Summary of Product Characteristics (SmPC) or British National Formulary (BNF) guidance