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doi: 10.1182/blood.2021012811 90 SaltarellaIMorabitoFGiulianiNTerragnaCOmedPPalumboAet al
doi: 10.1007/s00421-009-1328-7
doi: 10.1096/fasebj.11.6.9194528
Once telomeres become critically short, the cell enters senescence as a protective measure to avoid chromosomal instability and potential malignant transformation.12 Telomeres shorten with each cell division due to the end-replication problem in DNA synthesis
Angiogenesis, the formation of new blood vessels, represents the third critical mechanism
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