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Komaki Y, Komaki F, Ido A, Sakuraba A

Jin, Y., Tan, Y., Wu, J

To address these mechanistic differences, researchers propose integrating real-time microenvironmental monitoring technologies (e.g., PET imaging targeting lipid peroxidation products) with multi-omics gene expression profiling to dynamically assess ferroptosis-related pathway activities

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427,428 SIRT3-5 are mainly located in mitochondria and possess a mitochondrial targeting sequence, 429 while SIRT7 is primarily found in the nucleus, though fewer studies have addressed molecules that regulate its activity

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