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The first approved product, tisagenlecleucel (Kymriah) demonstrated remarkable results in patients with no other treatment options

This suggests the critical impact of XBP1 on intestinal epithelial repair and tissue homeostasis (Haring et al., 2022)

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In contrast, diseases in which there is a prolonged and chronic decrease in glutathione (GSH) do not respond well to NAC treatment

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The other hierarchic aspect is connected with the patterns of expression of certain potentially more essential selenoproteins (Novoselov et al., 2005) in certain tissues, first of all in the brain, to maintain these important selenoproteins at a high level even at Se deficiency