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Overall, the GPX4 pathway plays a crucial role in regulating ferroptosis by reducing lipid peroxides, maintaining membrane integrity, and regulating iron metabolism (Fig

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These neuropeptides can affect either the response of cortical cells in zona fasciculate to ACTH, the vascularization of cortex, its growth, or they may exert direct modulatory effects on the cortical cells themselves

Patel MY, Panchal HV, Ghribi O, Benzeroual KE (2012) The neuroprotective effect of fisetin in the MPTP model of Parkinsons disease

Redox Biol 27:101267 Ray PD, Huang BW, Tsuji Y (2012) Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling

Because research is limited, side-effect information is not as strong as it is for FDA-approved medications