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After the interaction between umamiGPCR, the subunit disconnects from the G complex and activates the enzyme phospholipase C, leading to generate IP3 (inositol triphosphate)

[DOI] [PMC free article] [PubMed] [Google Scholar] 167.Zhao Q-F, Yu J-T, Tan L

10.1158/1535-7163.MCT-10-1062

A ubiquitin-like system mediates protein lipidation

Oxidized LDL promotes OA by activating inflammatory pathways such as NF-kB and oxidative stress, leading to the generation of ROS and the expression of inflammatory mediators ( MMPs ), contributing to cartilage degradation in OA (143)

T2D is often accompanied by other components of MDS, such as preobesity/obesity, metabolic dysfunction associated steatotic liver disease, dyslipidemia, which usually occurs before it, and they are considered as the upstream diseases of T2D