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The substance must be the active ingredient in an FDA-approved drug, have a USP monograph, appear on the FDA's approved bulks list (Category 1), or have GRAS (Generally Recognized as Safe) status

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2025 doi: 10.1101/2025.01.13.632726

some treatments have limited efficacy

Nothing in this article constitutes a claim that any compounded product is clinically proven, has been evaluated in clinical trials, or produces the same results as any FDA-approved drug

Solution conditions determine the relative importance of nucleation and growth processes in alpha-synuclein aggregation