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The mitochondrial multienzyme pyruvate dehydrogenase complex irreversibly catalyzes the oxidative decarboxylation of pyruvate (a 3-carbon alpha-keto acid) into acetyl-CoA as the primary substrate for the tricarboxylic acid cycle

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Tau-S214 phosphorylation inhibits Fyn kinase interaction and increases the decay time of NMDAR-mediated current

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