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REDEFINE Trial Headlines Trial REDEFINE 1 Phase 3 Duration 68 weeks Population (N) 3,417 adults with obesity or overweight + 1 comorbidity, without T2D Key Result 20.4% mean weight change vs 3.0% placebo (treatment-policy)

For reference, these are the Recommended Dietary Allowances (RDA) for vitamin B12 by sex and age group indicating the daily amount needed for healthy individuals ( Men 1418: 2.4 mcg Men 19+: 2.4 mcg Women 1418: 2.4 mcg Women 19+: 2.4 mcg During pregnancy: 2.4 mcg During lactation: 2.8 mcg SUMMARY The RDA for vitamin B12 for most people is 2.4 mcg per day

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