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The initial hyperthyroid phase is caused by autoimmune destruction of thyroid follicles, leading to the release of preformed thyroid hormone into the circulation

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The reciprocal expression patterns of BDNF and the activity-dependent plasticity marker Arg3.1 further link this pathway to tinnitus perception: as acoustic trauma increased BDNF exon IV expression in spiral ganglion neurons, Arg3.1 expression was concurrently reduced in the AC

Gluckman PD, Johnson-Barrett JJ, Butler JH, Edgar BW, Gunn TR