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Studies have shown that ERCs can induce the polarization of M2 macrophages, tolerogenic dendritic cells, and regulatory T and B cells both in vivo and in vitro
Insulin signalling and the regulation of glucose and lipid metabolism
It improves renal function and renal lesions in diabetic rats [65]
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Nevertheless, currently available DNMT inhibitors are not sufficiently selective, leading to off-target adverse effects including global DNA hypomethylation, oncogene activation and increased genomic instability
