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Rheumatol Int 41:319328
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The latter is a potent but non-selective S1P receptor agonist, binding with similar affinity as S1P to S1P 1 , S1P 3 , S1P 4 and S1P 5 , but not S1P 2 [77]
However, doctors limit the number of these injections that a patient can have in a year to two or three
