glutathione peroxidase alzheimers disease peroxidase-1 and neuromodulation: Novel potentials of an old enzyme PDF) The role of glutathione
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So making glutathione depends on a well functioning methylation cycle that provides enough homocysteine

Hong ZG, Wei HS, Zhang LL, L F, Wu HG

Transforming growth factor-1 (TGF-1) has also been shown to regulate GSH synthesis at the level of GCLC in different cell types (Jardine et al., 2002

Our IV glutathione infusions are available both as standalone treatments and as an add-on to other wellness infusions, including Myers cocktail and NAD+ infusions

Nat Med 23:859868

If the B12 shot is painful, then your muscles impulsively flex as a reaction to the needles insertion
