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This review highlights the functional pathways and mechanisms, particularly gut microbe-induced chronic inflammation, protein misfolding, propagation of disease-specific pathology, defective protein clearance, and autoimmune dysregulation, linking gut microbial dysbiosis and neurodegeneration

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Sublingual absorption is at least partially passive, it doesn't require stomach acid or intrinsic factor, and high doses leverage a small passive-diffusion absorption pathway that operates independently of the intrinsic factor system

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