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& DiBartola, S

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Polyphenol health effects on cardiovascular and neurodegenerative disorders: a review and meta-analysis

In preclinical studies, metformin activates AMPK via inhibition of mitochondrial complex I, enhancing mitochondrial biogenesis and mitophagy [148], while pioglitazone promotes fatty acid oxidation, energy production, and reduces neuroinflammation [149]

However, this exfoliating effect only happens at high concentrations (20%) which can be hard to find in cosmetic products
