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doi: 10.1186/2046-2395-3-6

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Autophagy is increased after traumatic brain injury in mice and is partially inhibited by the antioxidant -glutamylcysteinyl ethyl ester

The ATP7B-KO cell line with stable PRNP knockdown (ATP7B-KO:PRNP-KD) was generated by infecting ATP7B-KO cells with pLKO1-puro-CMV-tGFP shPRNP-lentiviral particles (Mission lentiviral transduction particles, SigmaAldrich) and upon selection with puromycin

The rate of superoxide reacting with SOD is ~2 10 9 M 1 s 1

In addition, Zous group reported the induction of tumor cell ferroptosis due to the suppression of the GSH/GPX4 axis by CD8 + T cellmediated IFN- upon ICB (48), confirming a generalizable ferroptotic pathway also used by tumor cells for survival (6)