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Based on phase variation frequencies in hpuAB and hmbR , encoding two distinct hemoglobin receptors, Richardson and Stojiljkovic (2001) identified mutL alleles encoding MutL variants with multiple amino acid substitutions in MutL, associated with three distinct switching phenotypes, slow, medium, and fast, together with a mutS allelic variant associated with fast switch and high spontaneous mutation frequency to rifampicin-resistance

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Intracellular ATP inhibits this channel and activation of the channel upon metabolic inhibition or ATP consumption generates a hyperpolarizing current that reduces cellular excitability [28]

Through the synergistic action of these four mechanisms, bile acids collectively maintain the structural integrity and functional normality of the hepatopancreas