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Fibroblast-like synoviocyte (FLS) are the predominant cell types of synovial intima 5 and assure the structural and physiological integrity of diarthrodial joints, regulating the synovial fluid composition and the extracellular matrix of the joint lining 6

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The paracellular route takes the peptide between the epithelial cells, squeezing through the narrow spaces where cells meet