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This decrease in the nuclear translocation of p-NF-B and the expression of pro-inflammatory cytokines is not observed after GPR109A knockdown in RAW264.7 cells (Giri et al., The implication of a decrease in inflammation as measured by the GPR109A following niacin supplementation needs further investigation (Seamon et al., 2020) and may reflect on macrophage polarization modulation with niacin intervention

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Persistent inflammation and cigarette smoke are primary sources of ROS in the lung, causing redox imbalance and peroxidation damage to lipids, proteins, and nucleic acids ( in vitro

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Utricles were homogenized in a ground glass homogenizer (Wheaton Science, Millville, NJ, USA), and total RNA was collected using RNeasy Micro (Qiagen)

[DOI] [PMC free article] [PubMed] [Google Scholar] 67.Haferkamp S, Borst A, Adam C, Becker TM, Motschenbacher S, Windhovel S