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On the other hand, individuals with the CT and CC genotypes display reduced GSTM1 activity, making them prone to oxidative stress due to the genes diminished ability to scavenge oxidant species ( Similarly, the GSTM5 gene is part of the GST family and encodes the enzyme, glutathione S-transferase 5 (GSTM5) found in cellular compartments, such as the mitochondria
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N-acetylcysteine and Sulodexide have been found to mitigate endothelial damage
