glutathione signaling pathway The Role of Metabolism in Chronic Illness Development and Its Potential Use as a Novel Therapeutic Target Frontiers | Glutathione metabolism as

10.1016/j.bbcan.2012.10.003 142 MarquesO.OuteiroT

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One such gene is MALAT1, a long non-coding RNA located on chromosome 11q13.1 initially discovered in NSCLC, which also plays a regulatory role in vascular biology

Hyperglycemia leads to the activation of the pathways and the production of reactive oxygen species, and the increase of cytokines and chemokines such as IL-6 (interleukin 6), MCP-1 (monocyte chemoattractant protein-1), TGF- (transforming growth factor-), and VEGF (vascular endothelial growth factor) leads to inflammation, fibrosis, and increased vascular permeability [22]

J.KupryszewskiG.WitczukB.WiniewskiK

Subcellular targeting strategies for drug design and delivery