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People with pernicious anemia, diabetes, and other diseases may occasionally utilize methylcobalamin

Whether high folic-acid intake or high folate status causes altered renal handling of holoTC and increased urinary excretion of vitamin B-12 remains to be investigated

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Given that B12 is a water-soluble vitamin, the majority of an injected dose is excreted through urine, leaving only a small fraction for absorption

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