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Non-equilibrium supramolecular polymerization

This functional material is featured by TfR1-mediated BBB penetration and GBM targeting, and it exhibits significant antitumor effects by mediating profound mitochondrial dysfunction (180)

Additionally, lactate can be converted to pyruvate intra-mitochondrially via mitochondrial lactate dehydrogenase (mLDH), rather than by the cytosolic isoform (cLDH), a reaction that initiates entry into the tricarboxylic acid (TCA) cycle and oxidative phosphorylation

All experiments were done in the presence of 20 mM cysteine

The PI3K/AKT/mTOR signaling pathway is one of the important mechanisms of tamoxifen resistance, and HER2 activates PI3K as a member of the EGFR family ( p -AKT is associated with a worse prognosis, and inhibiting the expression of AKT is beneficial for sensitizing drug-resistant cells (Zhu et al., 2018), which makes the PI3K/AKT pathway particularly important in the treatment of breast cancer

Brain NAD is associated with ATP energy production and membrane phospholipid turnover in humans