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[9] Deep intramuscular administration into the gluteal muscle using a 22-gauge needle is recommended, and patients who self-inject must be trained in aseptic technique, site rotation and safe sharps disposal to reduce infection and tissue-injury risk

[DOI] [PMC free article] [PubMed] [Google Scholar] 159.Loh K

10.1186/s13046-021-02134-y J Exp Clin Cancer Res

However, in acute ischemia-reperfusion models, overexpression of HIF-1 can reduce pyroptosis markers (e.g., GSDMD cleavage products) and the release of IL-1 and IL-18 by inhibiting the ROS/NLRP3 pathway in microglia

Oxidative stress in chronic obstructive pulmonary disease: a lung and systemic process

Table 1 summarizes studies of cell engineering strategies and the corresponding levels of -PL obtained with different -PL producers, and the detailed information is discussed below