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Since its initial characterization, a central theme that has emerged is that ferroptosis represents a fundamental metabolic vulnerabilityone that arises when antioxidant systems fail to detoxify lipid hydroperoxides (LOOH) 1,8,9

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In fact, intrasplenic inoculation of B16 melanoma (B16M) cells into C57BL/6J syngenic mice induced metastatic foci formation by colonizing different organs

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