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A related compound, SBT-272 (bevemipretide trihydrochloride), displays similar CL-binding properties but higher brain bioavailability and mitochondrial uptake, particularly in ALS models [75]

The therapeutic benefits of glutathione were enhanced when combined with a medically healthy diet and lifestyle improvements, accelerating the recovery process

Interestingly, GST was increased in the midgut and decreased in the head, indicating tissue-dependent regulation of the synergetic effect
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However, this recycling process requires energy and other cofactors