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Diabetes 2014;64:156475

3.2.4 Ferroptosis and amyotrophic lateral sclerosis ALS is a lethal NDD characterized by progressive degeneration of upper and lower motor neurons in the cerebral cortex, brainstem, and spinal cord, leading to skeletal muscle atrophy, weakness, weight loss, dysarthria, dysphagia, paralysis, and ultimately death from respiratory failure (Feldman et al., 2022)

Production of reactive oxygen species (ROS) was monitored following 5-(and-6)-chloromethyl-2,7-dichlorodihydrofluorescein diacetate acetyl ester and MitoSOX Redderived fluorescence