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If there's one thing worth remembering, it's this: consistency beats precision

Hyperglucagonaemia in diabetes: altered amino acid metabolism triggers mTORC1 activation, which drives glucagon production

Specifically, the decrease in SIRT1 levels, inhibition of its activity, or generation of mutations that lower its activity have been linked to intestinal inflammation and colitis in human and rodent models (Caruso et al., 2014

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But the flip side is equally important

10.1016/j.mce.2016.10.010 [DOI] [PMC free article] [PubMed] [Google Scholar] 35.Yang Q, Chen X, Zheng T, Han D, Zhang H, Shi Y, Bian J, Sun X, Xia K, Liang X, Liu G, Zhang Y, Deng C