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Apart from clinical efficacy defined as the change in Hamilton Depression Rating Scale (HAMD)-17 score, secondary outcomes include changes in pathophysiological mechanisms related to depression as well as changes in local brain activity (functional Magnetic Resonance Imaging, fMRI) and white matter integrity (Diffusion Tensor Imaging, DTI)

doi: 10.2337/dc10-2268

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A nicotinic acid transporter (CIMG_06071) and a sialate transporter (CIMG_03956) were also upregulated

McGinnis, C

One study aiming to achieve this is the DecodeME study that launched September 2022 (586)