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Antioxidants 11, 2282

Autophagic degradation of ferritin in cytoplasm or lysosome, known as ferritinophagy, could lead to elevated intracellular iron levels, thereby accumulating ROS and eventually triggering ferroptotic cell death (Hou et al., 2016)

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Kuroda J, Kimura S, Strasser A, Andreeff M , O'Reilly LA, Ashihara E, Kamitsuji Y, Yokota A, Kawata E, Takeuchi M, Tanaka R, Tabe Y, Taniwaki M, Maekawa T

Stopping NUC treatment should therefore only be carried out under the supervision of an experienced physician, said the study leader

To strengthen the physiological relevance of our findings, we conducted additional experiments using iPSC-derived neurons carrying the P301L tau mutation