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10.1038/s41467-021-25236-9
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Nicorandil: an improver of coronary microvascular function Nicorandil, a hybrid molecule with potassium channel-opening and nitrate-like properties, has been shown to ameliorate Hcy-induced coronary microvascular dysfunction by modulating the PI3K/Akt/eNOS signaling pathway [122]

Li C, Wang H, Jiang Y, Fu W, Liu X, Zhong R, et al

The covalent C-Co bond is one of first examples of carbon-metal bonds in biology
The link is (surprise!) mitochondria
