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About 50% of the histamine in the brain is from mast cells.[ref] Diphenhydramine (Benadryl) has the side effect of making people sleepy due to blocking the actions of histamine in the brain

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[DOI] [PMC free article] [PubMed] [Google Scholar] 148.Prasad C, Imamura M, Debata C, Svec F, Sumar N, Hermon-Taylor J

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