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Phenotypes caused by pathogenic mtDNA mutations We next considered mtDNA sequence variation in UKB (Methods), with an initial focus on well-established, disease-associated mtDNA variants
Valenti D, Tullo A, Caratozzolo MF, Merafina RS, Scartezzini P, Marra E, Vacca RA

Heres how they support skin and overall wellness: Neutralise harmful free radicals that damage skin cells Reduce melanin production by shifting the pigment from dark eumelanin to light pheomelanin

These molecules work synergisticallyNAD+ provides energy for cellular processes while glutathione protects cells from oxidative damage

For instance, a common mutation in APP known as the Artic mutation increases A deposition while the mutation of PS1M146V PS results in elevated levels of readily aggregating A 42 [121-123]
10.1074/jbc.RA118.004889 [DOI] [PMC free article] [PubMed] [Google Scholar] Scoles DR, Minikel EV, & Pulst SM (2019)
