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FIGURE 11 Discussion In the present work, we demonstrated that individual-centric spheroids are reliable models to perform clinical trial-in-a-dish approaches to categorize less-DILI concern from most-DILI concern drugs, and importantly, to determine whether a compound causes majorly dose-dependent or dose-independent DILI

New pain management medications should exhibit higher response rates than existing options and aim to target specific pain pathways while improving understanding of dosing regimens and treatment cycles

The 0.9% concentration is carefully calibrated

The skin, which constitutes the outermost layer of the body, provides protection against external stimuli and performs various vital functions, such as regulating the release of inflammatory cytokines to defend the body when exposed to different environmental conditions [23, 31]

Chronic low-dose cadmium exposure disrupts gut microbiota and lipid metabolism to induce liver injury

Its name originates from studies on maternal-fetal and maternal-neonatal transmission of Ab immunity [15,16,17,18] and subsequent identification of the receptor itself in the intestinal epithelium of neonatal rodents [19], which at the time pointed to a role predominantly in the early stages of life