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Lorrain PE et al (2018): Neostigmine: Mechanism of Action, Dosing, and Factors Determining Adequacy of Recovery

[DOI] [PubMed] [Google Scholar] 67.Gupta VK, Scheunemann L, Eisenberg T, et al

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Following this initial phosphorylation cascade, phosphorylation of two other tyrosine residues (Y1349,Y1356) occurs and these residues serve as docking sites for downstream signaling molecules that mediate Ras/Raf, PI3K/Akt/mTOR, and/or STAT3 pathways (1315)

In terms of electrical remodeling, mitochondrial ROS decrease the activity of L-type Ca 2+ channels, resulting in a shortened action potential duration