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In the post-natal stage, the umbilical ring is formed when the mesoderm of muscle and fascia around the umbilical vessels and urachus contracts

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Persistent synovitis can induce VEGF production, promoting neovascularization and increased vascular permeability (143), which may facilitate the influx of iron into the joint cavity and subchondral bone and recruit additional immune cells, thereby intensifying local oxidative stress and inflammatory cascades (144)

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Changes in mRNA levels were assessed by qRT-PCR 57

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