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Autophagy--a key player in cellular and body metabolism

In a case-control study involving smokers with normal lung function, COPD, and lung cancer (COPD subtype), it was found that the GG genotype of the rs1489759 HHIP SNP and the CC genotype of the rs2202507 GYPA SNP exhibited a protective effect against both COPD (OR 0.59, p = 0.006 for HHIP and OR = 0.65, p = 0.006 for GYPA) and lung cancer (OR = 0.70, p = 0.05 for HHIP and OR = 0.70, p = 0.02 for GYPA) [139]

10.1186/1743-7075-8-34 [DOI] [PMC free article] [PubMed] [Google Scholar] 32.Mankad D, Dupuis A, Smile S, Roberts W, Brian J, Lui T, et al

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RSL3, an inhibitor of GPX4, covalently binds to GPX4 and inactivates GPX4, leading to the accumulation of intracellular peroxides and triggering ferroptosis (28)