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Moreover, pretreated cells displayed higher basal GCLC levels than cells without pretreatment, and the second NFT treatment led to a relatively modest additional increase (Fig

Comparison of the bioavailability of quercetin and catechin in rats

In parallel, a fluorescent sensor of caspase 3/7 activity showed that PRNP silencing significantly reduced the number of apoptotic cells upon exposure to Cu (Supplementary Fig

marina exhibit cytotoxic activity on lung cells via the ROS-dependent apoptosis machinery, recruiting both p53-dependent and -independent caspases [154, 155]

2 Aging, oxidative stress, and inflammation 2.1 Mechanisms of oxidative stress and chronic low-grade inflammation in aging Aging is delineated by a gradual disruption in the equilibrium between the synthesis of ROS and the efficacy of antioxidant defense mechanisms, resulting in a persistent condition of oxidative stress (Figure 1)

The 'one-size-fits-all' approach is rapidly becoming a relic of the past