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Studies published up to October 2024 were included, with an update in January 2025

doi: 10.1073/pnas.0910723107, 30

[DOI] [PubMed] [Google Scholar] 283

518,519 In addition, in pediatric UC patients, when treated with low-dose or high-dose vedolizumab on day 1 and at weeks 2, 6, and 14, respectively, significant efficacy was similarly demonstrated

This functional deterioration not only compromises the livers intrinsic capacity to manage mitochondrial stress but, more importantly, impairs its role as a central signaling hub, disrupting its ability to accurately sense, integrate, and transmit inter-organ communication cues (Sohn et al., 2023