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The majority of the functional LDH in mammalian cells contain various combinations two distinct types of LDH subunits, termed M (encoded by the LDHA gene) and H (encoded by the LDHB gene)

Finally, we discuss emerging strategies to interrogate and modulate this circuit using integrated omics, CRISPR-based screening, and pharmacological approaches, emphasizing the need for context-aware and temporally controlled metabolic interventions to enhance T cellbased immunotherapies in solid tumors

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individuals with these symptoms are encouraged to consider the therapeutic strategies below

doi: 10.1055/s-0044-1790258, 52

Similar to ICARIA-MM, the primary endpoint was PFS